How is papillary renal cell carcinoma (pRCC) graded?

Updated: Jul 02, 2019
  • Author: YiFen Zhang, MD, PhD; Chief Editor: Liang Cheng, MD  more...
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Answer

The ISUP/WHO grading system is validated for papilllary renal cell carcinoma (pRCC), [3, 4] whereas Furman grading has been shown to be unrelated to cancer-specific mortality in patients with pRCC. [21]  Studies have indicated that grading of pRCC should not be based on nucleolar prominence alone. [22] Similarly, Delahunt et al [22, 23] pointed out that none of the proposed grading systems for renal cell carcinoma (RCC) — including the Fuhrman grading system — provides prognostic information for chromophobe renal cell carcinoma (RCC). Nonetheless, investigations that include large series of cases are still required to demonstrate whether or not nuclear grade is an independent prognostic factor in papillary and chromophobe renal cell carcinomas (RCCs).


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