Which grading system is superior for clear cell renal cell carcinoma (ccRCC)?

Updated: Jul 02, 2019
  • Author: YiFen Zhang, MD, PhD; Chief Editor: Liang Cheng, MD  more...
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As noted earlier, the Fuhrman grading system has been extensively used by pathologists in Europe and the United States [12, 13, 14, 15] ; this system categorizes renal cell carcinoma (RCC) with grades 1, 2, 3, and 4 based on nuclear characteristics and has represented one of the most significant prognostic variables in patients with all stages of renal cell carcinoma (RCC). [2] The conventional Fuhrman grading system is validated for grading clear cell renal cell carcinoma (ccRCC), [2]  but the International Society of Urologic Pathologists (ISUP)/World Health Organization grading system has been shown to be superior to the Fuhrman grading system for this subtype of renal cell carcinoma (RCC).

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