What is the Fuhrman grading system for renal cell carcinoma (RCC)?

Updated: Jul 02, 2019
  • Author: YiFen Zhang, MD, PhD; Chief Editor: Liang Cheng, MD  more...
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Tumor stage is the key prognostic parameter in renal cell carcinoma (RCC). [1] The grading schema of renal cell carcinoma (RCC) is based on the microscopic morphology of a neoplasm with hematoxylin and eosin (H&E) staining. The most popular and used widely system for grading renal cell carcinoma (RCC) has been a nuclear grading system described in 1982 by Fuhrman et al, [2]  which concurrently evaluates nuclear size and shape, and nucleolar prominence. [3] However, discordance and grading imprecision may occur among these three parameters, rendering the Fuhrman grading inapplicable. [3]

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