What is the role of immunohistochemistry in the diagnosis of squamous cell carcinoma of the urinary bladder?

Updated: Jun 11, 2019
  • Author: Muhammad T Idrees, MD; Chief Editor: Liang Cheng, MD  more...
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Answer

Answer

The diagnosis of squamous cell carcinoma of the bladder is based primarily on the morphology. Immunohistochemical stains do not have a substantial role in diagnosing this tumor. CK20 has been seen in majority of urothelial carcinoma; however, in one study, none of the schistosomal-associated squamous cell carcinoma stained. Expression of cyclooxygenase-2 (COX-2) and uroplakin II has not been observed in any of the squamous cell carcinomas of the bladder, but they have been expressed in the majority of urothelial carcinomas. [43, 44]


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