Which immunohistochemical staining results are characteristic of stromal tumors of uncertain malignant potential (STUMP)?

Updated: Jan 04, 2021
  • Author: Fabio R Tavora, MD, PhD; Chief Editor: Liang Cheng, MD  more...
  • Print
Answer

Answer

Immunohistochemical staining of stromal tumors of uncertain malignant potential (STUMP) reveals positivity with vimentin, progesterone receptor, actin, and CD34 in variable amounts. [24] A few cases also show estrogen receptor positivity. Beta-catenin was reportedly positive in one case of STUMP.

Ki-67 proliferative index is low but not discriminatory from stromal sarcomas. Negativity for CD117 allows distinction from gastrointestinal stromal tumors in small biopsy samples.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!