How does tumor dedifferentiation affect the prognosis for prostate cancer following radiation therapy?

Updated: Dec 30, 2020
  • Author: Kenneth A Iczkowski, MD; Chief Editor: Liang Cheng, MD  more...
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Answer

Answer

Wheeler et al found that patients with dedifferentiation of locally recurrent prostate cancer after radiation therapy had poorer survival than did patients who retained their original tumor grade. On multiple variable logistic regression, time since treatment was the only factor predictive for dedifferentiation; thus, these researchers concluded that the dedifferentiation reflected time-dependent progression. [24]


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