Which histologic findings are characteristic of mantle cell lymphoma of the prostate?

Updated: Dec 22, 2019
  • Author: Joshua I Warrick, MD; Chief Editor: Liang Cheng, MD  more...
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Answer

Answer

Mantle cell lymphoma typically appears as a proliferation of monomorphic small lymphocytes with irregular, angulated nuclei and inconspicuous nucleoli. Tumors cells grow in an expansive, infiltrative manner. The typical immunophenotype is CD20+/CD10-/CD5+/Cyclin D1+.

See the images below.

Pathology of prostate leukemia and lymphoma. Mantl Pathology of prostate leukemia and lymphoma. Mantle cell lymphoma of the prostate. The tumor cells show an infiltrative pattern.
Pathology of prostate leukemia and lymphoma. Cycli Pathology of prostate leukemia and lymphoma. Cyclin D1 immunostain of a mantle cell lymphoma of the prostate.
Pathology of prostate leukemia and lymphoma. CD20 Pathology of prostate leukemia and lymphoma. CD20 immunostain of a mantle cell lymphoma of the prostate.

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