What is the etiopathogenesis of eosinophilic esophagitis (EoE)?

Updated: Jan 03, 2020
  • Author: Nina Tatevian, MD, PhD, FCAP; Chief Editor: Nirag C Jhala, MD, MBBS  more...
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Answer

Answer

The etiopathogenesis of eosinophilic esophagitis (EoE) is an evolving concept. Genome expression analysis of patients with EoE has shown a unique transcriptome, which includes several dysregulated genes leading to the inflammatory response. [58] Eotaxin 3 causes tissue eosinophilia. Desmoglein 1 is an intracellular adhesion molecule, which is downregulated in EoE. Interleukin 13 upregulation leads to increased expression of periostin in esophageal fibroblasts. Thymic stromal lymphopoeitin increases basophil responses in EoE. [58]


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