What is the prognosis for Lown-Ganong-Levine syndrome (LGL)?

Updated: Dec 09, 2020
  • Author: Daniel M Beyerbach, MD, PhD; Chief Editor: Jose M Dizon, MD  more...
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Answer

Regarding prognosis, no studies have shown an increased risk of sudden death or decreased survival for patients meeting criteria for diagnosis of Lown-Ganong-Levine syndrome.

Complications vary by the underlying condition. However, affected patients have a higher risk of developing tachyarrhythmias; caution should be used with certain medications (eg, sympathomimetics). [1]

Paroxysms of tachycardia represent the primary morbidity of this condition. Few data are available regarding the frequency of these paroxysms. Data regarding mortality from Lown-Ganong-Levine are scant. In their original report, Lown, Ganong, and Levine reported six patients with paroxysmal atrial fibrillation, two of whom suffered sudden cardiac death. [4]  Numbers in published studies are too small to estimate mortality rate with significant accuracy or confidence. In the absence of significant structural heart disease, the mortality rate appears to be very low.


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