What are contraindications for prasugrel for the treatment of unstable angina?

Updated: Oct 01, 2020
  • Author: Walter Tan, MD, MS; Chief Editor: Eric H Yang, MD  more...
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Answer

It should be noted that prasugrel remains unproven for use in patients with ST-elevation MI (STEMI) or ACS who were treated only medically. In addition, this agent must be withdrawn at least 7 days before planned CABG (compared with 5 days for clopidogrel or ticagrelor).

Prasugrel should not be used prior to coronary angiography. Thus, based on current guidelines, patients with unstable angina being treated with upfront dual antiplatelet therapy should be given either clopidogrel or ticagrelor.


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