How is Lown-Ganong-Levine (LGL) syndrome differentiated from Wolff-Parkinson-White (WPW) syndrome on ECG?

Updated: Jan 08, 2017
  • Author: Christopher R Ellis, MD, FACC, FHRS; Chief Editor: Mikhael F El-Chami, MD  more...
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Lown-Ganong-Levine (LGL) syndrome has a shortened PR interval because of the presence of the AP bypassing the AV node, but it has a normal QRS because the AP (James fibers) connects directly with the His bundle and does not depolarize the ventricles directly but depolarizes them via the typical conduction pathway through the His-Purkinje system. The true pathophysiology of this classic description has recently been brought into question.

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