What are the clinical manifestations of Wolff-Parkinson-White (WPW) syndrome?

Updated: Jan 08, 2017
  • Author: Christopher R Ellis, MD, FACC, FHRS; Chief Editor: Mikhael F El-Chami, MD  more...
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Wolff-Parkinson-White (WPW) syndrome can result in supraventricular tachycardia (SVT) that uses an arteriovenous accessory pathway (AP). The AP may also act as an innocent bystander and allow conduction during other supraventricular dysrhythmias, such as atrial fibrillation (AF) or atrial flutter. Paradoxically, the use of digoxin and perhaps other atrioventricular (AV) nodal blocking agents may favor conduction through the AP, causing potentially lethal ventricular dysrhythmias (ventricular fibrillation [VF]) or hemodynamic instability during AF.

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