What is the role of MYH6 variants in the etiology of Wolff-Parkinson-White (WPW) syndrome?

Updated: Jan 08, 2017
  • Author: Christopher R Ellis, MD, FACC, FHRS; Chief Editor: Mikhael F El-Chami, MD  more...
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More recently, investigators appeared to have identified a novel locus in a family with WPW, MYH6 p.E1885K. [14] All of the family members with WPW but none of the unaffected relatives demonstrated this variant. MYH6 variants have been associated with atrial septal defects, cardiomyopathies, and sick sinus syndrome. [14]

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