What are the medications used in the treatment of Wolff-Parkinson-White (WPW) syndrome?

Updated: Jan 08, 2017
  • Author: Christopher R Ellis, MD, FACC, FHRS; Chief Editor: Mikhael F El-Chami, MD  more...
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Oral medication is the mainstay of therapy in patients not undergoing radiofrequency ablation, although the response to long-term antiarrhythmic therapy for the prevention of further episodes of tachycardia in patients with WPW syndrome remains quite variable and unpredictable. Choices include the following:

  • Class Ic drugs (eg, flecainide, propafenone), typically used with an AV nodal blocking agent in low doses to avoid atrial flutter with a 1:1 conduction
  • Class III drugs (eg, amiodarone, sotalol), although these are less effective for altering accessory pathway conduction properties
  • In pregnancy, sotalol (class B) or flecainide (class C)

See Treatment and Medication for more detail.

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