Which medications in the drug class Antiarrhythmics, Class III are used in the treatment of Ventricular Tachycardia?

Updated: Dec 05, 2017
  • Author: Steven J Compton, MD, FACC, FACP, FHRS; Chief Editor: Jeffrey N Rottman, MD  more...
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Antiarrhythmics, Class III

Class III antiarrhythmics prolong the action potential duration. Some agents in this class inhibit adrenergic stimulation (alpha- and beta-blocking properties); affect sodium, potassium, and calcium channels; and prolong the action potential and refractory period in myocardial tissue. These effects result in decreased AV conduction and sinus node function.

Amiodarone (Cordarone, Pacerone, Nexterone)

Amiodarone is the drug of choice for the treatment of hemodynamically unstable VT that is refractory to other antiarrhythmic agents. Prehospital studies currently suggest that amiodarone is safe and efficacious for use in out-of-hospital cardiac arrest.

Sotalol (Betapace)

Sotalol is a class III antiarrhythmic that is primarily a potassium channel (IKr)-blocking drug with a weak beta-blocking effect. It is indicated for ventricular arrhythmias such as sustained VT. Because sotalol is renally cleared, renal function must be monitored.

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