What is the role of genetic therapies in the treatment of sinus node dysfunction (SND)?

Updated: Nov 30, 2018
  • Author: Bharat K Kantharia, MD, FRCP, FAHA, FACC, FESC, FHRS; Chief Editor: Mikhael F El-Chami, MD  more...
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Answer

Certain genetic mutations have been linked to sinus node and conduction system disease. SCN5A, HCN4, RYR2, CASQ2, and ankyrin-B (ANKB) mutations are associated with sinus node dysfunction, whereas mutations of SN5A, SCN1B, KCNJ2, TBX5, and NKX2-5 are associated with conduction system disease. Neuromuscular genetic disorders including emerin (EMD), lamin A/C (LMNA), and myotonic dystrophy type 1 (DM1) are also associated with AV conduction disease.[7] Gene- and stem cell-based therapies are currently being investigated as therapeutic options for patients with genetic or degenerative abnormalities of the cardiac electrical conduction system.


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