What is the efficacy of beta-blockers for the treatment of long QT syndrome (LQTS)?

Updated: Nov 29, 2017
  • Author: Ali A Sovari, MD, FACP, FACC; Chief Editor: Mikhael F El-Chami, MD  more...
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Answer

As previously mentioned, the protective effect of beta-blockers is related to their adrenergic blockade, which diminishes the risk of cardiac arrhythmias. They may also reduce the QT interval in some patients. Beta-blockers used in patients with LQTS include the following:

  • Nadolol (preferred)
  • Propranolol
  • Metoprolol
  • Atenolol

Nadolol is the preferred beta blocker to be used at a dose of 1-1.5 mg/kg/day (once a day for patients older than 12 years and divided twice a day for younger patients). [3]


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