What are the European Society of Cardiology (ESC) diagnostic guidelines for long QT syndrome (LQTS)?

Updated: Nov 29, 2017
  • Author: Ali A Sovari, MD, FACP, FACC; Chief Editor: Mikhael F El-Chami, MD  more...
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ESC recommendations

In 2015, the European Society of Cardiology (ESC) released guidelines for the management of ventricular arrhythmias and the prevention of sudden cardiac death (SCD) which included the following modified recommendation for the diagnosis of LQTS [37] :

Class I (Level of evidence: C)

LQTS is diagnosed when any of the following criteria is met:

  • QTc of at least 480 ms in repeated 12-lead ECGs
  • LQTS risk score above 3
  • Presence of a confirmed LQTS gene mutation, irrespective of the QT duration

Class IIa (Level of evidence: C)

LQTS should be considered in patients with an unexplained syncopal episode and a QTc of at least 460 ms in repeated 12-lead ECGs in the absence of secondary causes for QT prolongation

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