How does the prevalence of long QT syndrome (LQTS) vary by sex?

Updated: Nov 29, 2017
  • Author: Ali A Sovari, MD, FACP, FACC; Chief Editor: Mikhael F El-Chami, MD  more...
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Answer

Newly diagnosed cases of LQTS are more prevalent in female patients (60-70% of cases) than in male patients. The female predominance may be related to the relatively prolonged QTc (as determined by using the Bazett formula) in women compared to men and to a relatively higher mortality rate in young men.

In women, pregnancy is not associated with an increased incidence of cardiac events, whereas the postpartum period is associated with a substantially increased risk of cardiac events, especially in the subset of patients with LQT2. Cardiac events have been highly correlated with menses.

In addition, a significantly higher risk of cardiac events (a 3- to 8-fold increase, mainly in the form of recurrent episodes of syncope) has been reported in women with LQT2 syndrome during and after the onset of menopause, compared with the reproductive years. [18]


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