Which medications in the drug class Anti-inflammatory Agents are used in the treatment of Pericardial Effusion?

Updated: Nov 28, 2018
  • Author: William J Strimel, DO, FACP; Chief Editor: Terrence X O'Brien, MD, MS, FACC  more...
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Answer

Anti-inflammatory Agents

These agents inhibit key factors involved in inflammatory reactions.

Colchicine

Colchicine is an alkaloid extract that inhibits microtubule formation and has unique anti-inflammatory properties. The drug concentrates well in leukocytes and reduces neutrophilic chemotaxis and motility. Colchicine reduces the release of lactic acid and proinflammatory enzymes. It inhibits the release of histamine-containing granules from mast cells, which may be important in the pathogenesis of elastic tissue changes found in anetoderma.

The use of colchicine in autoimmune disease is primarily empiric, and the mechanism of action in the reduction of inflammation is not clear. Colchicine is not truly an immunomodulating agent.


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