What are the less common causes of pericardial effusion?

Updated: Nov 28, 2018
  • Author: William J Strimel, DO, FACP; Chief Editor: Terrence X O'Brien, MD, MS, FACC  more...
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Less common causes of pericardial effusion include the following:

  • Uremia

  • Myxedema

  • Severe pulmonary hypertension

  • Radiation therapy

  • Acute myocardial infarction - Including the complication of free wall rupture

  • Aortic dissection - Leading to hemorrhagic effusion from leakage into the pericardial sac

  • Trauma

  • Hyperlipidemia

  • Chylopericardium

  • Familial Mediterranean fever

  • Whipple disease

  • Hypersensitivity or autoimmune related -Systemic lupus erythematosus, [5] rheumatoid arthritis, ankylosing spondylitis, rheumatic fever, scleroderma, sarcoidosis, Wegener granulomatosis

  • Drug associated - Eg, procainamide, hydralazine, isoniazid, minoxidil, phenytoin, anticoagulants, methysergide

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