What is the role of cardiac biomarkers in the evaluation of acute pericarditis?

Updated: Apr 02, 2019
  • Author: Sean Spangler, MD; Chief Editor: Terrence X O'Brien, MD, MS, FACC  more...
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Answer

Evaluate cardiac biomarkers, such as creatine kinase and isoenzymes levels, as well as LDH and SGOT (AST) for associated myocarditis or myocardial infarction. Troponin I may be elevated in viral or idiopathic acute pericarditis.

In a study by Imazio and colleagues, an elevated troponin I level was found in 32% of patients with viral or idiopathic pericarditis. [34] In this study, the troponin I level was related to the extent of myocardial inflammation but was not a negative prognostic marker. [34] In a study by Machado et al, elevated troponin I levels were found to be associated with a significant increase in cardiac mortality in patients with myopericarditis compared with pericarditis only. [35]


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