What future and emerging therapies exist for the treatment of myocardial infarction (MI, heart attack)?

Updated: May 07, 2019
  • Author: A Maziar Zafari, MD, PhD, FACC, FAHA; Chief Editor: Eric H Yang, MD  more...
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Answer

Local injection of progenitor cells, growth factors, or stem cells may stimulate vascular development. Stem cell therapies for acute myocardial infarction (MI) remain a major target of research, with some data showing modest results. [124] Investigators in the Reinfusion of Enriched Progenitor Cells And Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) study examined 204 patients with acute ST-elevation MI (STEMI) and reported greater improvement in left ventricular ejection fraction (LVEF) among patients who received intracoronary progenitor cell infusion than among those given placebo. [125]

Several smaller clinical trials have suggested that intracoronary delivery of autologous bone marrow mononuclear cells (BMCs) have improved left ventricular function when administered within the first week following MI. However, results from the LateTIME Randomized Trial that evaluated whether intracoronary delivery of autologous BMCs delivered 2-3 weeks following first MI improved global and regional left ventricular function when compared with placebo suggested little improvement with this strategy in patients with MI and left ventricular dysfunction following reperfusion with percutaenous coronary intervention (PCI). [126]


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