What are the current clinical practice guidelines for the use of long-term statin therapy in acute myocardial infarction (MI, heart attack)?

Updated: May 07, 2019
  • Author: A Maziar Zafari, MD, PhD, FACC, FAHA; Chief Editor: Eric H Yang, MD  more...
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All patients with an acute MI should be started on high-potency statin therapy and continued indefinitely.

Current clinical practice guidelines, high potency statins such as atorvastatin 40 mg or 80 mg, or rosuvastatin 20 mg are recommended. [1, 2, 115]

The Effects of Atorvastatin on Early Recurrent Ischemic Events In Acute Coronary Syndromes (MIRACL) trial [116] and the Atorvastatin for Reduction of Myocardial Damage During Angioplasty-Acute Coronary Syndromes (ARMYDA-ACS) trial [117] demonstrated a reduction in mortality rates in patients who received high-potency statins after acute MI as compared to placebo.

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