What is the dosage regimen for unfractionated heparin (UH) in the treatment of non-ST-elevation acute coronary syndrome (unstable angina and NSTEMI), and what is its disadvantage?

Updated: May 07, 2019
  • Author: A Maziar Zafari, MD, PhD, FACC, FAHA; Chief Editor: Eric H Yang, MD  more...
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An initial loading dose of 60 IU/kg (maximum 4,000 IU) with an initial infusion of 12 IU/kg per hour (maximum 1,000 IU/h) adjusted per activated partial thromboplastin time (PTT) is recommended to maintain therapeutic anticoagulation according to the specific hospital protocol. This regimen is continued for 48 hours or until PCI is performed.

A major disadvantage of the use of unfractionated heparin is the large interindividual variability and narrow therapeutic window.

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