Which medications in the drug class Beta-Blockers, Beta-1 Selective are used in the treatment of Holiday Heart Syndrome?

Updated: May 30, 2018
  • Author: Lawrence Rosenthal, MD, PhD, FACC, FHRS; Chief Editor: Jose M Dizon, MD  more...
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Answer

Beta-Blockers, Beta-1 Selective

Beta-blockers (also known as beta-antagonists) function via sympatholytic effects. The beta-1 adrenoreceptor is the adrenoreceptor responsible for myocardial effects. Thus, beta-1 selective agents are generally preferred if possible to avoid off-target effects. In general, they are the treatment of choice in the setting of acute myocardial ischemia or left ventricular systolic dysfunction.

Metoprolol (Lopressor, Toprol XL)

Metoprolol is a beta-1 selective (ie, cardioselective) beta-blocker that may be given IV or PO for acute rate control.

Metoprolol is not avaliable as an infusion. Thus, once rate controlled, the patient must be switched to scheduled IV or PO doses.

Esmolol (Brevibloc)

Esmolol is another cardioselective beta-blocker. It is administered as an IV bolus with maintenance infusion. Its main clinical utility is its short half-life (9 minutes, with a clinical hemodynamic effect commonly quoted at 10-30 minutes).


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