Which medications in the drug class Antidysrhythmics, III are used in the treatment of Holiday Heart Syndrome?

Updated: May 30, 2018
  • Author: Lawrence Rosenthal, MD, PhD, FACC, FHRS; Chief Editor: Jose M Dizon, MD  more...
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Antidysrhythmics, III

Class III antiarrhythmic agents inhibit adrenergic stimulation; affect sodium, potassium, and calcium channels; markedly prolong action potential and repolarization; and decrease atrioventricular conduction and sinus node function.

Amiodarone (Cordarone, Nexterone, Pacerone)

Amiodarone is perhaps the most effective of all the antiarrhythmic drugs. It has effects in all four of the Vaughn Williams antiarrhythmic classes. In general, however, amiodarone should not be a first-line agent. When used for acute rate control in the acute setting, only IV amiodarone is practical. It is useful for rate control when heart failure or hypotension are present, as amiodarone tends to cause less hypotension than beta-blockers and calcium channel blockers.  

NOTE: There is a theoretical concern for cardioversion with amiodarone which must be considered if selecting this drug.  

In this particular context of alcohol-induced atrial fibrillation, keep in mind that amiodarone is also associated with many adverse effects, one of which is hepatotoxicity.

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