What is the role of biomarkers in coronary artery atherosclerosis screening?

Updated: Apr 09, 2021
  • Author: Sandy N Shah, DO, MBA, FACC, FACP, FACOI; Chief Editor: Yasmine S Ali, MD, MSCI, FACC, FACP  more...
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Answer

In a 10-year comparison of 10 biomarkers for predicting death and first major cardiovascular events in approximately 3000 individuals, the most informative biomarkers for predicting death were the following [32] :

The most informative biomarkers for predicting major cardiovascular events were B-type natriuretic peptide and the urinary albumin-to-creatinine ratio. Individuals with elevated multimarker scores had a risk of death 4 times higher and a risk of major cardiovascular events almost 2 times higher than those with low multimarker scores. However, the use of multiple biomarkers added only moderately to the overall prediction of risk based on conventional cardiovascular risk factors.

In a study that evaluated four potential biomarkers of endothelial health in 34 patients with mature collateral networks who successfully underwent percutaneous coronary intervention (PCI) for chronic total coronary occlusion (CTO) before the procedure and 6-8 postsurgery, there were no signficant changes in system levels of sICAM-1, sE-selectin, microparticles, or tissue factor 6-8 weeks following PCI. [33] Although the investigators noted an association between estimated retrograde collateral flow before the CTO recanalization and these four biomarkers, they attributed this relationship as being associated with an ability to develop collaterals as opposed to their presence and extent.


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