What are the racial predilections of coronary artery atherosclerosis?

Updated: Apr 09, 2021
  • Author: Sandy N Shah, DO, MBA, FACC, FACP, FACOI; Chief Editor: Yasmine S Ali, MD, MSCI, FACC, FACP  more...
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Answer

The incidence, prevalence, and manifestations of CAD vary significantly with race, as does the response to therapy.

African Americans appear to have higher morbidity and mortality rates of CAD, even when the statistics are corrected for educational and socioeconomic status. The risk-factor burden experienced by African Americans differs from that of Caucasian Americans. The prevalence of hypertension, obesity, dysmetabolic syndrome, and lack of physical activity are much higher in African Americans, whereas the prevalence of hypercholesterolemia is lower. African Americans with AMI present for treatment later than patients do on average, are less often subjected to invasive strategies, and experience greater overall mortality. (Similar statistics can also be cited for presentation and treatment of patients with stable CAD.)

Asian Indians exhibit a 2- to 3-fold higher prevalence of CAD than do whites in the United States. They also have greater prevalences of hypoalphalipoproteinemia, high lipoprotein(a) levels, and diabetes.


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