Which medications are used in the treatment of coronary artery atherosclerosis?

Updated: Apr 09, 2021
  • Author: Sandy N Shah, DO, MBA, FACC, FACP, FACOI; Chief Editor: Yasmine S Ali, MD, MSCI, FACC, FACP  more...
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The following are used in the management of angina [1] :

  • Nitrates

  • Beta blockers

  • Calcium channel blockers

  • Ranolazine

Other agents used in the treatment of coronary artery stenosis or to aid in the management of coronary artery disease after intervention, or for the presentation of acute coronary syndromes, include the following:

  • Angiotensin-converting enzyme inhibitors to reduce blood pressure

  • Antiplatelet agents for acute coronary events

  • Intravenous glycoprotein IIb/IIIa inhibitors

  • Aspirin

  • Thienopyridine antiplatelet agents (e.g., clopidogrel, prasugrel)

  • Ticagrelor

  • HMG-CoA reductase inhibitors, or statins, to lower LDL cholesterol levels and stabilize atherosclerotic plaque

  • PCSK-9 inhibitors in select high-risk patients with known CAD and need for additional LDL lowering

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