What are the goals of antiretroviral therapy for treatment-experienced patients with HIV infection?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Answer

Answer

The goals of therapy in treatment-experienced patients are the same as in treatment-naive patients. [8] With the introduction of newer agents, suppression of viremia to below the limit of assay detection is now achievable in many patients who harbor drug-resistant viral strains.

Genotypic or phenotypic resistance testing should be used to assist with selection of appropriate therapy and should be obtained while patients remain on their previous therapy or within 4 weeks of discontinuation to improve the sensitivity of results. Phenotypic testing is generally added to genotypic testing when complex drug resistance mutation patterns, especially to protease inhibitors, are confirmed or suspected. [8]


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