What are the DHHS ART guidelines for regimen selection in antiretroviral therapy of HIV infection?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Answer

Answer

The antiretroviral regimen selected should be based on patient-specific factors and preferences. Factors to consider include associated comorbidities, the adverse-effect profiles of the medications being considered, the potential for pregnancy, adherence barriers, regimen convenience, and potential drug-food and drug-drug interactions. Resistance testing findings should also be considered in the initial regimen selection.

Certain agents require consideration of other factors (e.g., HLA-B*5701 testing for abacavir hypersensitivity, pretreatment CD4 count for nevirapine, pretreatment viral load for rilpivirine) before their use. [8]


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