What are the DHHS ART guidelines for antiretroviral resistance testing in HIV treatment naïve patients?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Preexisting antiretroviral resistance can be detected in 6-16% of treatment-naive individuals. [8] Based on this possibility, DHHS guidelines recommend that resistance testing be performed in all patients with HIV infection at the onset of care.

Genotypes are generally the test of choice, as de novo resistance to NRTIs or NNRTIs is most commonly observed. Genotypes are also less costly and exhibit a shorter turnaround time. If the interval between entering care and beginning antiretroviral therapy is significant, it is generally recommended that the patient undergo testing with another genotype prior to therapy initiation to assess any resistance acquired in the interim. [8]

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