What is the rate of discontinuation of chemokine receptor antagonists in antiretroviral therapy of HIV infection due to adverse effects?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Answer

The rate of discontinuation due to adverse effects was similar to that found with placebo (4.9% and 5.3%, respectively). Postural hypotension is a dose-limiting effect that was discovered early in the development of maraviroc. In pooled analysis, postural hypotension occurred only in patients who received maraviroc at doses that exceeded 600 mg/day. The manufacturer warns that severe hepatotoxicity has been reported with maraviroc; caution should be used when maraviroc is administered to any patient predisposed to hepatic impairment. [97]


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