What are the adverse effects of fusion inhibitors (FIs) in antiretroviral therapy of HIV infection?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Answer

Most patients receiving enfuvirtide experience injection-site reactions, increasing drug discontinuation rates. Manifestations include subcutaneous nodules, erythema, pruritus, pain, and ecchymoses. Other adverse effects that occur to a lesser extent include diarrhea, nausea, and fatigue. Hypersensitivity reactions have been described but are rare. Enfuvirtide has been associated with an increased risk for bacterial pneumonia, but causality has not been established. [94, 95]


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