What causes the resistance to protease inhibitors in antiretroviral therapy of HIV infection?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Answer

Answer

Resistance to HIV protease inhibitors results from mutations both inside and outside the active protease domain. [43] Resistance typically occurs through the development of one or more major mutations, which produce conformational changes in the protease binding site, followed by secondary compensatory mutations that improve enzymatic activity and, in some cases, viral fitness. [43]


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