What are the ibalizumab (Trogarzo) dosing guidelines for antiretroviral therapy of HIV infection?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Answer

Answer

Ibalizumab (Trogarzo) (approved only for antiretroviral treatment–experienced patients with drug resistance):

  • Dosage forms: 150mg/mL(200mg/1.33mL single-dose vial)
  • Adult dose: First dose (single loading dose), 2000 mg IV infused over at least 30 min (begin maintenance doses 2 weeks after loading dose); maintenance doses, 800 mg IV q2Weeks infused over at least 15-30 min
  • Adverse events: Diarrhea, dizziness, nausea, and rash reported in 5-8% of patients; immune reconstitution syndrome reported in 1 patient

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