What are the dolutegravir (Tivicay) dosing guidelines for antiretroviral therapy of HIV infection?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Answer

Answer

Dolutegravir (Tivicay):

  • Dosage forms: 50-mg tablet
  • Adult dose: 50 mg PO once daily; with UGT1A/CY3A inducers (e.g., efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, rifampin) or designated INSTI resistance mutations, 50 mg PO BID
  • Comments: Take without regard to meals
  • Adverse events: Cholesterol and TG elevations, CK elevations, liver enzyme elevations, hyperglycemia

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