What are the raltegravir (Isentress, Isentress HD) dosing guidelines for antiretroviral therapy of HIV infection?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Answer

Answer

Raltegravir (Isentress, Isentress HD):

  • Dosage forms: 400-mg tablet, 600-mg tablet
  • Adult dose: Isentress, 400 mg PO bid; Isentress with rifampin,  800 mg PO bid; Isentress HD, 1200 mg PO once daily (for use in treatment-naïve or virologically suppressed on an initial regimen of 400 mg bid)
  • Comments: Take without regard to meals
  • Adverse events: Nausea, diarrhea, headache, CK elevations, myopathy/rhabdomyolysis (rare)

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