What are the tipranavir (Aptivus) dosing guidelines for antiretroviral therapy of HIV infection?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Answer

Answer

Tipranavir (Aptivus) (approved only for antiretroviral treatment–experienced patients with drug resistance):

  • Dosage forms: 250-mg soft gelatin capsule; 100-mg/mL oral solution
  • Adult dose: 500 mg + ritonavir 200 mg PO bid without regard to meals
  • Comments: Unboosted tipranavir is not recommended
  • Adverse events: Hepatotoxicity, rash, hyperlipidemia, hyperglycemia, intracranial hemorrhage (rare cases reported)

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