What are the ritonavir (Norvir) dosing guidelines for antiretroviral therapy of HIV infection?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Ritonavir (Norvir):

  • Dosage forms: 100-mg tablet; 100-mg soft gelatin capsule; 80-mg/mL oral solution
  • Adult dose: Boosting dose for other protease inhibitors, 100-400 mg/d (refer to other protease inhibitors for specific dose); nonboosting dose (ritonavir used as sole protease inhibitor), 600 mg bid (titrate dose over 14 days, beginning with 300 mg bid on days 1-2, 400 mg bid on days 3-5, and 500 mg bid on days 6-13)
  • Comments: Tablet, take with food; capsule or oral solution, food improves tolerability
  • Adverse events: Nausea, vomiting, diarrhea, asthenia, hyperlipidemia, oral paresthesias, hyperglycemia

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