What are the lopinavir/ritonavir (Kaletra) dosing guidelines for antiretroviral therapy of HIV infection?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Answer

Answer

Lopinavir/ritonavir (Kaletra):

  • Dosage forms: 100-mg/25-mg, 200-mg/50-mg tablets; 80-mg/20-mg per mL oral solution
  • Adult dose: 400 mg/100 mg PO bid or 800 mg/200 mg PO qd (approved only for antiretroviral treatment–naïve patients or treatment-experienced patients without lopinavir-resistance mutations)
  • Comments: Tablet, take without regard to meals; oral solution: take with meals
  • Adverse events: Nausea, vomiting, diarrhea, asthenia, hyperlipidemia, hyperglycemia

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