What are the darunavir (Prezista) dosing guidelines for antiretroviral therapy of HIV infection?

Updated: Apr 18, 2019
  • Author: R Chris Rathbun, PharmD, BCPS (AQ-ID), AAHIVP; Chief Editor: John Bartlett, MD  more...
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Answer

Answer

Darunavir (Prezista):

  • Dosage forms: 75-mg, 150-mg, 300-mg, 400-mg, 600-mg tablets
  • Adult dose: 800 mg qd + ritonavir 100 mg PO qd or cobicistat 150 mg PO qd (approved only for antiretroviral treatment–naïve patients or  treatment-experienced patients without darunavir-resistance mutations); 600 mg bid + ritonavir 100 mg PO bid (treatment-experienced patients)
  • Comments: Take with food
  • Adverse events: Rash, nausea, diarrhea, hyperlipidemia, hyperglycemia

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