Which medications in the drug class Mood Stabilizers are used in the treatment of Narcissistic Personality Disorder?

Updated: May 16, 2018
  • Author: Sheenie Ambardar, MD; Chief Editor: David Bienenfeld, MD  more...
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Mood Stabilizers

Mood stabilizers such as lamotrigine may be used in adult patients with NPD to help with affect regulation and impulse control. The literature also contains some mention of the use of medications such as valproic acid and Lithium as mood stabilizers.

Lamotrigine (Lamictal)

Lamotrigine is an anticonvulsant that appears to be effective in the treatment of the depressed phase in bipolar disorders.

Valproic acid, divalproex sodium (Depakote, Depakene, Depacon, Stavzor)

Valproic acid is the most widely used agent in its class. It is modestly effective and generally well tolerated. It is chemically unrelated to other drugs that treat seizure disorders. Although its mechanism of action is not established, its activity may be related to increased brain levels of gamma-aminobutyric acid (GABA) or enhanced GABA action. It also may potentiate postsynaptic GABA responses, affect potassium channels, or have a direct membrane-stabilizing effect.

Lithium (Lithobid)

Lithium is indicated to treat bipolar disorder. The specific mechanism of action is unknown, but the drug alters sodium transport in nerve and muscle cells and influences reuptake of serotonin, norepinephrine, or both at cell membranes.

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