Which medications in the drug class Salicylates are used in the treatment of Wellens Syndrome?

Updated: Jan 25, 2018
  • Author: Benjamin B Mattingly, MD; Chief Editor: Erik D Schraga, MD  more...
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Answer

Salicylates

Salicylates have antiplatelet properties.

Aspirin (Ecotrin, Ascriptin, Bayer Aspirin, Bayer Aspirin Extra Strength, Tri-Buffered Aspirin)

Aspirin is an odorless white powdery substance that is available in 81-mg, 325-mg, and 500-mg tablets for oral use. When exposed to moisture, it hydrolyzes into salicylic acid and acetic acids. Aspirin is a stronger inhibitor of both prostaglandin synthesis and platelet aggregation than other salicylic acid derivatives are. Its acetyl group is responsible for inactivation of cyclooxygenase via acetylation. Aspirin is hydrolyzed rapidly in plasma, and elimination follows zero-order pharmacokinetics.

Aspirin irreversibly inhibits platelet aggregation by inhibiting platelet cyclooxygenase. This, in turn, inhibits conversion of arachidonic acid to prostaglandin I2 (PGI2, a potent vasodilator and inhibitor of platelet activation) and thromboxane A2 (TXA2, a potent vasoconstrictor and platelet aggregator). Platelet inhibition lasts for the life of cell (approximately 10 days).

Aspirin may be used in low doses to inhibit platelet aggregation and improve complications of venous stasis and thrombosis. It reduces the likelihood of myocardial infarction (MI) and is also very effective in lowering the risk of stroke. Early administration of aspirin in patients with acute MI may reduce cardiac mortality in the first month.


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