Which medications in the drug class Antidysrhythmics, Class V are used in the treatment of Atrial Flutter?

Updated: Nov 18, 2019
  • Author: Lawrence Rosenthal, MD, PhD, FACC, FHRS; Chief Editor: Jeffrey N Rottman, MD  more...
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Antidysrhythmics, Class V

Cardiac glycosides decrease AV nodal conduction primarily by increasing vagal tone. They are used mainly in the context of atrial fibrillation and atrial flutter with congestive heart failure.

Digoxin (Lanoxin)

Digitalis slows sinus node and AV node conduction via a vagomimetic effect and is not very effective if sympathetic tone is increased. It has direct inotropic effects in addition to indirect effects on the cardiovascular system.

The effects on myocardium involve both direct action on cardiac muscle that increases myocardial systolic contractions and indirect actions that result in increased carotid sinus nerve activity and enhanced sympathetic withdrawal for any given increase in mean arterial pressure. This agent is generally not recommended unless depressed left ventricular function is present.

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