What are the genetic causes of atrial flutter (AFL)?

Updated: Nov 18, 2019
  • Author: Lawrence Rosenthal, MD, PhD, FACC, FHRS; Chief Editor: Jeffrey N Rottman, MD  more...
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Although there are no clearly defined genetic conditions that cause atrial flutter, in many cases there is likely an underlying genetic susceptibility to acquiring it. Genome-wide association studies have identified genes associated with atrial flutter. [2]

The PITX2 (paired-like homeodomain 2) gene on chromosome locus 4q25 is known to play a major role in left-right asymmetry of the heart and has been found to have a strong association with atrial fibrillation [3] and an even stronger association with typical atrial flutter. [4] There are not yet any clinically available genetic tests that can identify persons at increased risk for atrial flutter.

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