What effect does aspirin as monotherapy for atrial fibrillation (Afib) (AF) have on the risk of stroke?

Updated: Nov 18, 2019
  • Author: Lawrence Rosenthal, MD, PhD, FACC, FHRS; Chief Editor: Jeffrey N Rottman, MD  more...
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Results from a retrospective study by Sjalander et al of 115,185 Swedish patients with AF indicated that aspirin as monotherapy not only did not protect against stroke, but it was also associated with an increased risk of ischemic stroke and thromboembolic events in elderly patients, as compared with no antithrombotic treatment. [64] In the study, 58,671 patients received aspirin monotherapy, whereas 56,514 did not receive any antithrombotic treatment at baseline; mean follow-up was 1.5 years.

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