What is the role of depression in the etiology of burning mouth syndrome (BMS)?

Updated: Apr 15, 2021
  • Author: Vincent D Eusterman, MD, DDS; Chief Editor: Arlen D Meyers, MD, MBA  more...
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Endogenous or reactive depression has been implicated; however, depression is strongly associated with anxiety. [21, 38] Whether depression is directly connected to burning mouth syndrome (BMS) is unclear. Serotonin deficiency has been suggested as a possible mechanism for sensory alterations in burning mouth syndrome (BMS) because of its role in the descending inhibition of pain.

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