What is the pathophysiology of burning mouth syndrome (BMS)?

Updated: Apr 15, 2021
  • Author: Vincent D Eusterman, MD, DDS; Chief Editor: Arlen D Meyers, MD, MBA  more...
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The pathophysiology of burning mouth syndrome (BMS) is not understood.

It was originally considered a psychogenic illness; however, a neuropathic mechanism for burning mouth syndrome (BMS) is currently favored. This is based on objectively measured abnormalities of physiologic responses of the trigeminal nerve in burning mouth syndrome (BMS) patients. [7, 8] There is also evidence to suggest histopathologic changes in nociceptive fibers in BMS patients. [9] The differentiation between a peripheral versus a central etiology has not been determined.

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